This book constitutes the thoroughly refereed post-proceedings of the 8th International Workshop on DNA Based Computers, DNA8, held in Sapporo, Japan, in June 2002.

The 30 revised full papers presented were carefully selected during two rounds of reviewing and improvement from an initial total of 68 submissions. The papers are organized in topical sections on self-assembly and autonomous molecular computation, molecular evolution and application to biotechnology, applications to mathematical problems, nucleic acid sequence design, and theory.